Structure of PDB 5deu Chain A Binding Site BS01

Receptor Information
>5deu Chain A (length=413) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SCRCVEQIIEKDEGPFYTHLGAGPNVAAIREIMEERFGQKGKAIRIERVI
YTGKEGKSSQGCPIAKWVVRRSSSEEKLLCLVRERAGHTCEAAVIVILIL
VWEGIPLSLADKLYSELTETLRKYGTLTNRRCALNEERTCACQGLDPETC
GASFSFGCSWSMYYNGCKFARSKIPRKFKLLGDDPKEEEKLESHLQNLST
LMAPTYKKLAPDAYNNQIEYEHRAPECRLGLKEGRPFSGVTACLDFCAHA
HRDLHNMQNGSTLVCTLTREDNREFGGKPEDEQLHVLPLYKVSDVDEFGS
VEAQEEKKRSGAIQVLSSFRRKVRMLAEPVKTCGSDEVWSDSEQSFLDPD
IGGVAVAPTHGSILIECAKRELHATTPLKNPNRNHPTRISLVFYQHKSMN
EPKHGLALWEAKM
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5deu Structural insight into substrate preference for TET-mediated oxidation.
Resolution1.801 Å
Binding residue
(original residue number in PDB)		R1261 R1262 S1286 S1290 Y1294 K1299 S1303 T1372 D1384 H1386 N1387 Y1902 H1904
Binding residue
(residue number reindexed from 1)		R130 R131 S155 S159 Y163 K168 S172 T241 D253 H255 N256 Y394 H396
Binding affinityPDBbind-CN: Kd=1.08uM
Enzymatic activity
Enzyme Commision number 1.14.11.80: methylcytosine dioxygenase.
Gene Ontology
Molecular Function
GO:0070579 5-methylcytosine dioxygenase activity
Biological Process
GO:0141166 chromosomal 5-methylcytosine DNA demethylation pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5deu, PDBe:5deu, PDBj:5deu
PDBsum5deu
PubMed26524525
UniProtQ6N021|TET2_HUMAN Methylcytosine dioxygenase TET2 (Gene Name=TET2)

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