Structure of PDB 5dej Chain A Binding Site BS01

Receptor Information

>5dej Chain A (length=116) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

CPLMVKVLDDVRGSPAINVAVHVFRKAADDTWEPFASGKTSESGELHGLT
TEEEFVEGIYKVEIDTKSYWKALGISPFHEHAEVVFTANDSGPRRYTIAA
LLSPYSYSTTAVVTNP

Ligand information

InChI=1S/Ca/q+2

BHPQYMZQTOCNFJ-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Ca++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Ca+2]

Formula

Ca

Name

CALCIUM ION

PDB chain

5dej Chain A Residue 201 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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PDB	5dej Crystal structure of human Transthyretin natural mutant A19D
Resolution	1.37 Å
Binding residue (original residue number in PDB)	E86 D119
Binding residue (residue number reindexed from 1)	E57 D90
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005179	hormone activity
GO:0005515	protein binding
GO:0042802	identical protein binding
GO:0070324	thyroid hormone binding

	Biological Process
GO:0006144	purine nucleobase metabolic process
GO:0007165	signal transduction

	Cellular Component
GO:0005576	extracellular region
GO:0005615	extracellular space
GO:0005737	cytoplasm
GO:0035578	azurophil granule lumen
GO:0070062	extracellular exosome

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Cellular Component

External links

PDB	RCSB:5dej, PDBe:5dej, PDBj:5dej
PDBsum	5dej
PubMed
UniProt	P02766\|TTHY_HUMAN Transthyretin (Gene Name=TTR)

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