Structure of PDB 5d9y Chain A Binding Site BS01

Receptor Information
>5d9y Chain A (length=413) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SCRCVEQIIEKDEGPFYTHLGAGPNVAAIREIMEERFGQKGKAIRIERVI
YTGKEGKSSQGCPIAKWVVRRSSSEEKLLCLVRERAGHTCEAAVIVILIL
VWEGIPLSLADKLYSELTETLRKYGTLTNRRCALNEERTCACQGLDPETC
GASFSFGCSWSMYYNGCKFARSKIPRKFKLLGDDPKEEEKLESHLQNLST
LMAPTYKKLAPDAYNNQIEYEHRAPECRLGLKEGRPFSGVTACLDFCAHA
HRDLHNMQNGSTLVCTLTREDNREFGGKPEDEQLHVLPLYKVSDVDEFGS
VEAQEEKKRSGAIQVLSSFRRKVRMLAEPVKTCGSDEVWSDSEQSFLDPD
IGGVAVAPTHGSILIECAKRELHATTPLKNPNRNHPTRISLVFYQHKSMN
EPKHGLALWEAKM
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5d9y Structural insight into substrate preference for TET-mediated oxidation.
Resolution1.971 Å
Binding residue
(original residue number in PDB)		R1261 R1262 S1286 S1290 M1293 Y1294 K1299 R1302 S1303 T1372 T1463 Y1902 H1904
Binding residue
(residue number reindexed from 1)		R130 R131 S155 S159 M162 Y163 K168 R171 S172 T241 T332 Y394 H396
Binding affinityPDBbind-CN: Kd=0.9uM
Enzymatic activity
Enzyme Commision number 1.14.11.80: methylcytosine dioxygenase.
Gene Ontology
Molecular Function
GO:0070579 5-methylcytosine dioxygenase activity
Biological Process
GO:0141166 chromosomal 5-methylcytosine DNA demethylation pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5d9y, PDBe:5d9y, PDBj:5d9y
PDBsum5d9y
PubMed26524525
UniProtQ6N021|TET2_HUMAN Methylcytosine dioxygenase TET2 (Gene Name=TET2)

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