Structure of PDB 5czh Chain A Binding Site BS01

Receptor Information
>5czh Chain A (length=311) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GEAPNQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIK
ELREATSPKANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPF
GCLLDYVREHKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLV
KTPQHVKITDFGRAKLLGAEEKEYHAEGGKVPIKWMALESILHRIYTHQS
DVWSYGVTVWELMTFGSKPYDGIPASEISSILEKGERLPQPPICTIDVYM
IMVKCWMIDADSRPKFRELIIEFSKMARDPQRYLVIQGDERMHLPDEEDM
DDVVDADEYLI
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5czh EGF-receptor specificity for phosphotyrosine-primed substrates provides signal integration with Src.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		D837 R841 G873 G874 K875 V876 P877 K879 W880 P919 A920
Binding residue
(residue number reindexed from 1)		D142 R146 G178 G179 K180 V181 P182 K184 W185 P224 A225
Enzymatic activity
Catalytic site (original residue number in PDB) D837 A839 R841 N842 D855
Catalytic site (residue number reindexed from 1) D142 A144 R146 N147 D160
Enzyme Commision number 2.7.10.1: receptor protein-tyrosine kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0004713 protein tyrosine kinase activity
GO:0005524 ATP binding
Biological Process
GO:0006468 protein phosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:5czh, PDBe:5czh, PDBj:5czh
PDBsum5czh
PubMed26551075
UniProtP00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)

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