Structure of PDB 5cw6 Chain A Binding Site BS01

Receptor Information
>5cw6 Chain A (length=151) Species: 7955 (Danio rerio) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MAVNAVHLESDAFLVCMNHALSTEEVMGLCIGEVDTNRIVHIHSVIILRR
VEISPEQLSAASTEAERLAEMTGRPMRVVGWYHSHPHITVWPSHVDVRTQ
AMYQMMDQGFVGLIFSCFIEDKNTKTGRVLYTCFQSVGSEYERIEIPIHV
V
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5cw6 Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5cw6 Higher-Order Assembly of BRCC36-KIAA0157 Is Required for DUB Activity and Biological Function.
Resolution3.193 Å
Binding residue
(original residue number in PDB)		H92 H94 D105
Binding residue
(residue number reindexed from 1)		H83 H85 D96
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.19.-
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0031593 polyubiquitin modification-dependent protein binding
GO:0046872 metal ion binding
Biological Process
GO:0001525 angiogenesis
GO:0006281 DNA repair
GO:0006302 double-strand break repair
GO:0006508 proteolysis
GO:0051301 cell division
GO:0070536 protein K63-linked deubiquitination
Cellular Component
GO:0000922 spindle pole
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005856 cytoskeleton
GO:0070531 BRCA1-A complex
GO:0070552 BRISC complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5cw6, PDBe:5cw6, PDBj:5cw6
PDBsum5cw6
PubMed26344097
UniProtA0A8M3B525|BRCC3_DANRE Lys-63-specific deubiquitinase (Gene Name=brcc3)

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