Structure of PDB 5cvm Chain A Binding Site BS01

Receptor Information
>5cvm Chain A (length=308) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HYFGLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQKKKENLLTCLAD
LFHSIATQKKKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTI
ADILQEEKKQELTWVHEIFQGTLTNETRCLNCETVSSKDEDFLDLSVDVE
QNTSITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILAL
HLKRFKYMEQLHRYTKLSYRVVFPLELRLFNTSNLDRMYDLVAVVVHCGS
GPNRGHYITIVKSHGFWLLFDDDIVEKIDAQAIEEFYGLTSDISKNSESG
YILFYQSR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5cvm Chain A Residue 1000 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5cvm Structural Insights into WD-Repeat 48 Activation of Ubiquitin-Specific Protease 46.
Resolution1.9 Å
Binding residue
(original residue number in PDB)		C182 C185 C229 C232
Binding residue
(residue number reindexed from 1)		C129 C132 C176 C179
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) N39 C44 H313 D328
Catalytic site (residue number reindexed from 1) N7 C12 H256 D271
Enzyme Commision number 3.4.19.12: ubiquitinyl hydrolase 1.
Gene Ontology
Molecular Function
GO:0004843 cysteine-type deubiquitinase activity
GO:0005515 protein binding
GO:0008234 cysteine-type peptidase activity
GO:0046872 metal ion binding
GO:0101005 deubiquitinase activity
Biological Process
GO:0001662 behavioral fear response
GO:0006508 proteolysis
GO:0008343 adult feeding behavior
GO:0016579 protein deubiquitination
GO:0032228 regulation of synaptic transmission, GABAergic
GO:0048149 behavioral response to ethanol
GO:0060013 righting reflex
Cellular Component
GO:0005634 nucleus
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5cvm, PDBe:5cvm, PDBj:5cvm
PDBsum5cvm
PubMed26388029
UniProtP62068|UBP46_HUMAN Ubiquitin carboxyl-terminal hydrolase 46 (Gene Name=USP46)

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