Structure of PDB 5cvd Chain A Binding Site BS01

Receptor Information

>5cvd Chain A (length=231) Species: 9606 (Homo sapiens)

GLVPRGSHMTSEVIEDEKQFYSKAKTYWKQIPPTVDGMLGGYGHISSIDI
NSSRKFLQRFLREGPNKTGTSCALDCGAGIGRITKRLLLPLFREVDMVDI
TEDFLVQAKTYLGEEGKRVRNYFCCGLQDFTPEPDSYDVIWIQWVIGHLT
DQHLAEFLRRCKGSLRPNGIIVIKDNMAQEGVILDDVDSSVCRDLDVVRR
IICSAGLSLLAEERQENLPDEIYHVYSFALR

Ligand information

>5cvd Chain D (length=6) Species: 9606 (Homo sapiens)

GPRRRS

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5cvd Molecular basis for histone N-terminal methylation by NRMT1
• Resolution: 1.3 Å
• Binding residue (original residue number in PDB): W20 L31 Y34 W136 D180 D212 E213 I214 Y215
• Binding residue (residue number reindexed from 1): W28 L39 Y42 W144 D188 D220 E221 I222 Y223

Enzymatic activity

• Enzyme Commision number: 2.1.1.244: protein N-terminal methyltransferase.

Gene Ontology

Molecular Function

• GO:0005515 protein binding
• GO:0008168 methyltransferase activity
• GO:0008276 protein methyltransferase activity
• GO:0042054 histone methyltransferase activity
• GO:0071885 N-terminal protein N-methyltransferase activity

Biological Process

• GO:0006338 chromatin remodeling
• GO:0006480 N-terminal protein amino acid methylation
• GO:0007051 spindle organization
• GO:0007059 chromosome segregation
• GO:0018012 N-terminal peptidyl-alanine trimethylation
• GO:0018013 N-terminal peptidyl-glycine methylation
• GO:0018016 N-terminal peptidyl-proline dimethylation
• GO:0032259 methylation
• GO:0035572 N-terminal peptidyl-serine dimethylation
• GO:0035573 N-terminal peptidyl-serine trimethylation

Cellular Component

• GO:0005634 nucleus
• GO:0005654 nucleoplasm
• GO:0005737 cytoplasm
• GO:0005829 cytosol

External links

• PDB: RCSB:5cvd, PDBe:5cvd, PDBj:5cvd
• PDBsum: 5cvd
• PubMed: 26543159
• UniProt: Q9BV86|NTM1A_HUMAN N-terminal Xaa-Pro-Lys N-methyltransferase 1 (Gene Name=NTMT1)