Structure of PDB 5cr0 Chain A Binding Site BS01

Receptor Information
>5cr0 Chain A (length=246) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ESVPVLELFSNIWGAGTKTAQMWYQQGFRSLEDIRSQASLTTQQAIGLKH
YSDFLERMPREEATEIEQTVQKAAQAFNSGLLCVACGSYRRGKATCGDVD
VAITHPDGRSHRGIFSRLLDSLRQEGFLTDDLVSQEENGQQQKYLGVCRL
PGPGRRHRRLDIIVVPYSEFACALLYFTGSAHFNRSMRALAKTKGMSLSE
HALSTAVVRNTHGCKVGPGRVLPTPTEKDVFRLLGLPYREPAERDW
Ligand information
Receptor-Ligand Complex Structure
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PDB5cr0 Structural Mechanism for the Fidelity Modulation of DNA Polymerase lambda
Resolution2.75 Å
Binding residue
(original residue number in PDB)		W342 G343 G345 K347 T348 D427 D429 R488 D490 Y505 F506 T507 A510 N513
Binding residue
(residue number reindexed from 1)		W13 G14 G16 K18 T19 D98 D100 R159 D161 Y176 F177 T178 A181 N184
Enzymatic activity
Catalytic site (original residue number in PDB) D427 D429 D490
Catalytic site (residue number reindexed from 1) D98 D100 D161
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
4.2.99.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0034061 DNA polymerase activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:5cr0, PDBe:5cr0, PDBj:5cr0
PDBsum5cr0
PubMed26836966
UniProtQ9UGP5|DPOLL_HUMAN DNA polymerase lambda (Gene Name=POLL)

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