Structure of PDB 5cc1 Chain A Binding Site BS01
Receptor Information
>5cc1 Chain A (length=75) Species:
9606
(Homo sapiens) [
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PPKLCLVCGDEASGCHYGVLTCGSCKVFFKRAVEGQHNYLCAGRNDCIID
KIRRKNCPACRYRKCLQAGMNLEAR
Ligand information
>5cc1 Chain C (length=18) [
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ccagaacagagtgttctg
Receptor-Ligand Complex Structure
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PDB
5cc1
Distal substitutions drive divergent DNA specificity among paralogous transcription factors through subdivision of conformational space.
Resolution
2.302 Å
Binding residue
(original residue number in PDB)
C431 H432 Y433 K442 K446
Binding residue
(residue number reindexed from 1)
C15 H16 Y17 K26 K30
Binding affinity
PDBbind-CN
: Kd=0.085uM
Enzymatic activity
Enzyme Commision number
?
Gene Ontology
Molecular Function
GO:0003700
DNA-binding transcription factor activity
GO:0008270
zinc ion binding
GO:0043565
sequence-specific DNA binding
Biological Process
GO:0006355
regulation of DNA-templated transcription
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Molecular Function
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Biological Process
External links
PDB
RCSB:5cc1
,
PDBe:5cc1
,
PDBj:5cc1
PDBsum
5cc1
PubMed
26715749
UniProt
P04150
|GCR_HUMAN Glucocorticoid receptor (Gene Name=NR3C1)
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