Structure of PDB 5c3u Chain A Binding Site BS01

Receptor Information
>5c3u Chain A (length=315) Species: 1031333 (Rhizomucor miehei CAU432) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QSLHVATPLLHAPNLTKELECNVFLKMENIQPSGSVKMRGIGAFCYQAVQ
TRGTNIQFVCGSGPNTVLAVSYCARQLGVEAIIVVPKATNERICQSIRTD
GSHLILYGENWTAAEVHARKLVRRNGIYVPSSDHALIWQGHSTIVQELKT
QLNDNPPAAIICPVGGGGLLNGVIMGLQEADWKDVPVIAVETHGSNAFQA
SVVAGELVIMEKNNTIATSLISKAVSSKSLELSLNHPVVPFAVSDAMAAD
AVRLFAEDFKMLVEASAGAALSLCYTHLIRDILPSLSPAKDVVVLVTGGS
DISLAHLDEYRKKYM
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain5c3u Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5c3u Crystal structure and characterization of a novel l-serine ammonia-lyase from Rhizomucor miehei.
Resolution1.76 Å
Binding residue
(original residue number in PDB)		K52 N80 S147 P178 G180 G181 G182 G183 S234 T312
Binding residue
(residue number reindexed from 1)		K37 N65 S132 P163 G165 G166 G167 G168 S219 T297
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) K52 G78 E206 S210 A212 S234 T312
Catalytic site (residue number reindexed from 1) K37 G63 E191 S195 A197 S219 T297
Enzyme Commision number 4.3.1.17: L-serine ammonia-lyase.
Gene Ontology
Molecular Function
GO:0003941 L-serine ammonia-lyase activity
GO:0004794 threonine deaminase activity
Biological Process
GO:0006565 L-serine catabolic process
GO:0006567 threonine catabolic process
GO:0009097 isoleucine biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5c3u, PDBe:5c3u, PDBj:5c3u
PDBsum5c3u
PubMed26367174
UniProtA0A0X1KHE6

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