Structure of PDB 5c1d Chain A Binding Site BS01

Receptor Information

>5c1d Chain A (length=695) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

THADSLNNLANIKREQGNIEEAVRLYRKALEVFPEFAAAHSNLASVLQQQ
GKLQEALMHYKEAIRISPTFADAYSNMGNTLKEMQDVQGALQCYTRAIQI
NPAFADAHSNLASIHKDSGNIPEAIASYRTALKLKPDFPDAYCNLAHCLQ
IVCDWTDYDERMKKLVSIVADQLEKNRLPSVHPHHSMLYPLSHGFRKAIA
ERHGNLCLDKINVLHKPPYEHPKDLKLSDGRLRVGYVSSDFGNHPTSHLM
QSIPGMHNPDKFEVFCYALSPDDGTNFRVKVMAEANHFIDLSQIPCNGKA
ADRIHQDGIHILVNMNGYTKGARNELFALRPAPIQAMWLGYPGTSGALFM
DYIITDQETSPAEVAEQYSEKLAYMPHTFFIGDHANMFPHLKKKAVIDFK
SIYDNRIVLNGIDLKAFLDSLPDVKIVKMLNMPVIPMNTIAEAVIEMINR
GQIQITINGFSISNGLATTQINNKAATGEEVPRTIIVTTRSQYGLPEDAI
VYCNFNQLYKIDPSTLQMWANILKRVPNSVLWLLRFPAVGEPNIQQYAQN
MGLPQNRIIFSPVAPKEEHVRRGQLADVCLDTPLCNGHTTGMDVLWAGTP
MVTMPGETLASRVAASQLTCLGCLELIAKNRQEYEDIAVKLGTDLEYLKK
VRGKVWKQRISSPLFNTKQYTMELERLYLQMWEHYAAGNKPDHMI

Ligand information

>5c1d Chain C (length=7) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

VTPVSTA

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5c1d The active site of O-GlcNAc transferase imposes constraints on substrate sequence.
Resolution	2.05 Å
Binding residue (original residue number in PDB)	H496 H499 N557 P559 T633 K634 Q839
Binding residue (residue number reindexed from 1)	H182 H185 N243 P245 T319 K320 Q507

Enzymatic activity

Enzyme Commision number

2.4.1.255: protein O-GlcNAc transferase.

External links

PDB	RCSB:5c1d, PDBe:5c1d, PDBj:5c1d
PDBsum	5c1d
PubMed	26237509
UniProt	O15294\|OGT1_HUMAN UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (Gene Name=OGT)

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