Structure of PDB 5c0y Chain A Binding Site BS01

Receptor Information

>5c0y Chain A (length=386) Species: 559292 (Saccharomyces cerevisiae S288C)

KRVEKPQLKFKSPIDNSESHPFIPLLKEKPNALKPLSESLRLVDDDPSHY
PHPYEYEIDHQEYSPEILQIREEIPSKSWDDSVPIWVDTSTELESMLEDL
KNTKEIAVDLEHHDYRSYYGIVCLMQISTRERDYLVDTLKLRENLHILNE
VFTNPSIVKVFHGAFMNIIWLQRDLGLYVVGLFDTYHASKAIGLPRHSLA
YLLENFANFKTSKKYQLADWRIRPLSKPMTAYARADTHFLLNIYDQLRNK
LIESNKLAGVLYESRNVAKRRFEYSKYRPLTPSSEVYSPIEKESPWKILM
YQYNIPPEREVLVRELYQWRDLIARRDDESPRFVMPNQLLAALVAYTPTD
VIGVVSLTNGVTEHVRQNAKLLANLIRDALRNIKNT

Ligand information

>5c0y Chain C (length=5)

uuuuu

.....

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5c0y RNA degradation paths in a 12-subunit nuclear exosome complex.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): Y244 R461 V490
• Binding residue (residue number reindexed from 1): Y115 R332 V361

Enzymatic activity

• Catalytic site (original residue number in PDB): D238 E240 N296 Y361 D365
• Catalytic site (residue number reindexed from 1): D109 E111 N167 Y232 D236
• Enzyme Commision number: 3.1.13.-

Gene Ontology

Molecular Function

• GO:0000166 nucleotide binding
• GO:0000175 3'-5'-RNA exonuclease activity
• GO:0003676 nucleic acid binding
• GO:0008408 3'-5' exonuclease activity

Biological Process

• GO:0000467 exonucleolytic trimming to generate mature 3'-end of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
• GO:0006139 nucleobase-containing compound metabolic process
• GO:0044237 cellular metabolic process

External links

• PDB: RCSB:5c0y, PDBe:5c0y, PDBj:5c0y
• PDBsum: 5c0y
• PubMed: 26222026
• UniProt: Q12149|RRP6_YEAST Exosome complex exonuclease RRP6 (Gene Name=RRP6)