Structure of PDB 5c0i Chain A Binding Site BS01
Receptor Information
>5c0i Chain A (length=277) Species:
9606
(Homo sapiens) [
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MGSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQRMEPRA
PWIEQEGPEYWDGETRKVKAHSQTHRVDLGTLRGYYNQSEAGSHTVQRMY
GCDVGSDWRFLRGYHQYAYDGKDYIALKEDLRSWTAADMAAQTTKHKWEA
AHVAEQLRAYLEGTCVEWLRRYLENGKETLQRTDAPKTHMTHHAVSDHEA
TLRCWALSFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVV
PSGQEQRYTCHVQHEGLPKPLTLRWEP
Ligand information
>5c0i Chain C (length=10) Species:
9606
(Homo sapiens) [
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RQFGPDFPTI
Receptor-Ligand Complex Structure
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PDB
5c0i
Hotspot autoimmune T cell receptor binding underlies pathogen and insulin peptide cross-reactivity.
Resolution
1.53 Å
Binding residue
(original residue number in PDB)
Y7 M45 E63 K66 V67 A69 H70 T73 D77 T80 L81 R97 Y99 H114 Y116 T143 K146 W147 L156 Y159 W167 Y171
Binding residue
(residue number reindexed from 1)
Y8 M46 E64 K67 V68 A70 H71 T74 D78 T81 L82 R98 Y100 H115 Y117 T144 K147 W148 L157 Y160 W168 Y172
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:5c0i
,
PDBe:5c0i
,
PDBj:5c0i
PDBsum
5c0i
PubMed
27183389
UniProt
P04439
|HLAA_HUMAN HLA class I histocompatibility antigen, A alpha chain (Gene Name=HLA-A)
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