Structure of PDB 5bxu Chain A Binding Site BS01
Receptor Information
>5bxu Chain A (length=163) Species:
9606
(Homo sapiens) [
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GSGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAG
YNRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVV
NVADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDG
DTDIQDLLRGDAA
Ligand information
>5bxu Chain B (length=8) Species:
9606
(Homo sapiens) [
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REAGDGAE
Receptor-Ligand Complex Structure
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PDB
5bxu
Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase.
Resolution
1.35 Å
Binding residue
(original residue number in PDB)
R525 S527 F532 G535 Y536 L560 N565 Y569 H571 D589 W591 F593 E598 K604
Binding residue
(residue number reindexed from 1)
R40 S42 F47 G50 Y51 L75 N80 Y84 H86 D104 W106 F108 E113 K119
Enzymatic activity
Enzyme Commision number
2.4.2.-
2.4.2.30
: NAD(+) ADP-ribosyltransferase.
External links
PDB
RCSB:5bxu
,
PDBe:5bxu
,
PDBj:5bxu
PDBsum
5bxu
PubMed
UniProt
Q9H2K2
|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)
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