Structure of PDB 5bxo Chain A Binding Site BS01
Receptor Information
>5bxo Chain A (length=160) Species:
9606
(Homo sapiens) [
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SGNSEADRQLLEAAKAGDVETVKKLCTVQSVNCRDIEGRQSTPLHFAAGY
NRVSVVEYLLQHGADVHAKDKGGLVPLHNACSYGHYEVAELLVKHGAVVN
VADLWKFTPLHEAAAKGKYEICKLLLQHGADPTKKNRDGNTPLDLVKDGD
TDIQDLLRGD
Ligand information
>5bxo Chain C (length=8) Species:
9606
(Homo sapiens) [
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REAGDGAE
Receptor-Ligand Complex Structure
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PDB
5bxo
Macrocyclized Extended Peptides: Inhibiting the Substrate-Recognition Domain of Tankyrase.
Resolution
1.334 Å
Binding residue
(original residue number in PDB)
R525 S527 F532 G535 Y536 L560 N565 Y569 H571 D589 W591 F593 E598 K602
Binding residue
(residue number reindexed from 1)
R39 S41 F46 G49 Y50 L74 N79 Y83 H85 D103 W105 F107 E112 K116
Enzymatic activity
Enzyme Commision number
2.4.2.-
2.4.2.30
: NAD(+) ADP-ribosyltransferase.
External links
PDB
RCSB:5bxo
,
PDBe:5bxo
,
PDBj:5bxo
PDBsum
5bxo
PubMed
28084734
UniProt
Q9H2K2
|TNKS2_HUMAN Poly [ADP-ribose] polymerase tankyrase-2 (Gene Name=TNKS2)
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