Structure of PDB 5bwl Chain A Binding Site BS01

Receptor Information
>5bwl Chain A (length=267) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PSSSMADFRKFFAKAKHIVIISGAGVSAESGVPTFRGAGGYWRKWQAQDL
ATPLAFAHNPSRVWEFYHYRREVMGSKEPNAGHRAIAECETRLGKQGRRV
VVITQNIDELHRKAGTKNLLEIHGSLFKTRCTSCGVVAENYKSPICPALS
GKGAPEPGTQDASIPVEKLPRCEEAGCGGLLRPHVVWFGENLDPAILEEV
DRELAHCDLCLVVGTSSVVYPAAMFAPQVAARGVPVAEFNTETTPATNRF
RFHFQGPCGTTLPEALA
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5bwl Crystal Structure of SIRT5 in Complex with a Coumarin-Labelled Succinyl Peptide
Resolution1.548 Å
Binding residue
(original residue number in PDB)		Y102 R105 I142 V221 W222 G224 E225 L227 L232 Y255 M259
Binding residue
(residue number reindexed from 1)		Y67 R70 I107 V186 W187 G189 E190 L192 L197 Y220 M224
Enzymatic activity
Catalytic site (original residue number in PDB) V67 P68 T69 F70 R71 N141 D143 H158
Catalytic site (residue number reindexed from 1) V32 P33 T34 F35 R36 N106 D108 H123
Enzyme Commision number 2.3.1.-
Gene Ontology
Molecular Function
GO:0036054 protein-malonyllysine demalonylase activity
GO:0036055 protein-succinyllysine desuccinylase activity
GO:0070403 NAD+ binding

View graph for
Molecular Function
External links
PDB RCSB:5bwl, PDBe:5bwl, PDBj:5bwl
PDBsum5bwl
PubMed
UniProtQ9NXA8|SIR5_HUMAN NAD-dependent protein deacylase sirtuin-5, mitochondrial (Gene Name=SIRT5)

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