Structure of PDB 5brz Chain A Binding Site BS01
Receptor Information
>5brz Chain A (length=275) Species:
9606
(Homo sapiens) [
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GSHSMRYFFTSVSRPGRGEPRFIAVGYVDDTQFVRFDSDAASQKMEPRAP
WIEQEGPEYWDQETRNMKAHSQTDRANLGTLRGYYNQSEDGSHTIQIMYG
CDVGPDGRFLRGYRQDAYDGKDYIALNEDLRSWTAADMAAQITKRKWEAV
HAAEQRRVYLEGRCVDGLRRYLENGKETLQRTDPPKTHMTHHPISDHEAT
LRCWALGFYPAEITLTWQRDGEDQTQDTELVETRPAGDGTFQKWAAVVVP
SGEEQRYTCHVQHEGLPKPLTLRWP
Ligand information
>5brz Chain C (length=9) Species:
9606
(Homo sapiens) [
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EVDPIGHLY
Receptor-Ligand Complex Structure
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PDB
5brz
Direct molecular mimicry enables off-target cardiovascular toxicity by an enhanced affinity TCR designed for cancer immunotherapy.
Resolution
2.62 Å
Binding residue
(original residue number in PDB)
Y7 E63 N77 L81 Y84 Y99 D116 T143 K146 W147 A152 Q155 R156 Y159 R163 R170 Y171
Binding residue
(residue number reindexed from 1)
Y7 E63 N77 L81 Y84 Y99 D116 T143 K146 W147 A152 Q155 R156 Y159 R163 R170 Y171
Enzymatic activity
Enzyme Commision number
?
External links
PDB
RCSB:5brz
,
PDBe:5brz
,
PDBj:5brz
PDBsum
5brz
PubMed
26758806
UniProt
P04439
|HLAA_HUMAN HLA class I histocompatibility antigen, A alpha chain (Gene Name=HLA-A)
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