Structure of PDB 5brk Chain A Binding Site BS01

Receptor Information

>5brk Chain A (length=194) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SKTFKPKKNIPEELLKHAEATLGSGNLRQAVMLPEGEDLNEWIAVNTVDF
FNQINMLYGTITEFCTEASCPVMSAGPRYEYHWADGTPIKCSAPKYIDYL
MTWVQDQLDDETLFPSKIGVPFPKNFMSVAKTILKRLFRVYAHIYHQHFD
SVMQLQEEAHLNTSFKHFIFFVQEFNLIDRRELAPLQELIEKLG

Ligand information

Ligand ID

InChI

InChI=1S/Zn/q+2

InChIKey

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Name

ZINC ION

PDB chain

5brk Chain A Residue 301 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5brk Structural basis for Mob1-dependent activation of the core Mst-Lats kinase cascade in Hippo signaling.
Resolution	2.3 Å
Binding residue (original residue number in PDB)	C79 C84 H161 H166
Binding residue (residue number reindexed from 1)	C65 C70 H143 H148
Annotation score	4

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0005515	protein binding
GO:0030295	protein kinase activator activity
GO:0043539	protein serine/threonine kinase activator activity
GO:0046872	metal ion binding

	Biological Process
GO:0035329	hippo signaling

	Cellular Component
GO:0005634	nucleus
GO:0005737	cytoplasm
GO:0005829	cytosol
GO:0070062	extracellular exosome

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Molecular Function

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Biological Process

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Cellular Component

External links

PDB	RCSB:5brk, PDBe:5brk, PDBj:5brk
PDBsum	5brk
PubMed	26108669
UniProt	Q9H8S9\|MOB1A_HUMAN MOB kinase activator 1A (Gene Name=MOB1A)

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