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PDB	5bpu Structure and functional properties of Norrin mimic Wnt for signalling with Frizzled4, Lrp5/6, and proteoglycan.
Resolution	2.4 Å
Binding residue (original residue number in PDB)	R38 C39 M40 R41 Y122 L124 C128
Binding residue (residue number reindexed from 1)	R8 C9 M10 R11 Y92 L94 C98

Molecular Function

frizzled binding

cytokine activity

protein binding

protein homodimerization activity

	Biological Process
GO:0000278	mitotic cell cycle
GO:0000320	re-entry into mitotic cell cycle
GO:0001508	action potential
GO:0001525	angiogenesis
GO:0001666	response to hypoxia
GO:0001890	placenta development
GO:0001974	blood vessel remodeling
GO:0002088	lens development in camera-type eye
GO:0003406	retinal pigment epithelium development
GO:0003407	neural retina development
GO:0006099	tricarboxylic acid cycle
GO:0006366	transcription by RNA polymerase II
GO:0006544	glycine metabolic process
GO:0006622	protein targeting to lysosome
GO:0006749	glutathione metabolic process
GO:0006954	inflammatory response
GO:0007033	vacuole organization
GO:0007179	transforming growth factor beta receptor signaling pathway
GO:0007224	smoothened signaling pathway
GO:0007399	nervous system development
GO:0007601	visual perception
GO:0008104	protein localization
GO:0008283	cell population proliferation
GO:0009069	serine family amino acid metabolic process
GO:0010467	gene expression
GO:0010842	retina layer formation
GO:0014004	microglia differentiation
GO:0016055	Wnt signaling pathway
GO:0016358	dendrite development
GO:0016567	protein ubiquitination
GO:0021554	optic nerve development
GO:0030182	neuron differentiation
GO:0031290	retinal ganglion cell axon guidance
GO:0035426	extracellular matrix-cell signaling
GO:0035640	exploration behavior
GO:0045446	endothelial cell differentiation
GO:0045893	positive regulation of DNA-templated transcription
GO:0046697	decidualization
GO:0048678	response to axon injury
GO:0051091	positive regulation of DNA-binding transcription factor activity
GO:0051402	neuron apoptotic process
GO:0051897	positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
GO:0060041	retina development in camera-type eye
GO:0060042	retina morphogenesis in camera-type eye
GO:0060070	canonical Wnt signaling pathway
GO:0060221	retinal rod cell differentiation
GO:0060856	establishment of blood-brain barrier
GO:0060996	dendritic spine development
GO:0061298	retina vasculature development in camera-type eye
GO:0061299	retina vasculature morphogenesis in camera-type eye
GO:0061304	retinal blood vessel morphogenesis
GO:0061518	microglial cell proliferation
GO:0070086	ubiquitin-dependent endocytosis
GO:0071456	cellular response to hypoxia
GO:0097601	retina blood vessel maintenance
GO:0110135	Norrin signaling pathway
GO:1904390	cone retinal bipolar cell differentiation
GO:1990963	establishment of blood-retinal barrier

Biological Process

GO:0000278

mitotic cell cycle

GO:0000320

re-entry into mitotic cell cycle

action potential

angiogenesis

response to hypoxia