Structure of PDB 5b6g Chain A Binding Site BS01

Receptor Information
>5b6g Chain A (length=331) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HHHMLHLLEQIRAYCETCWEWQEAHNPMPAPVEHQICPAVCVLMKLSFDE
EHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAGMALTNLTF
GDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLSWRADVNSK
KTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTENKADICAVD
GALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDHRQILRENN
CLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMGAVSMLKNL
IHSKHKMIAMGSAAALRNLMANRPAKYKDAN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5b6g Peptidomimetic inhibitors of APC-Asef interaction block colorectal cancer migration.
Resolution1.99 Å
Binding residue
(original residue number in PDB)		F458 R463 M503 T506 N507 F510 G511 K516 Q542 V543 R549 N550 W553 S590 W593 N594 A597 N641
Binding residue
(residue number reindexed from 1)		F48 R53 M93 T96 N97 F100 G101 K106 Q132 V133 R139 N140 W143 S180 W183 N184 A187 N231
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008013 beta-catenin binding
Biological Process
GO:0030178 negative regulation of Wnt signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5b6g, PDBe:5b6g, PDBj:5b6g
PDBsum5b6g
PubMed28759015
UniProtP25054|APC_HUMAN Adenomatous polyposis coli protein (Gene Name=APC)

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