Structure of PDB 5b56 Chain A Binding Site BS01

Receptor Information

>5b56 Chain A (length=429) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

NQGTVNWSVEDIVKGINSNNLESQLQATQAARKLLSREKQPPIDNIIRAG
LIPKFVSFLGKTDCSPIQFESAWALTNIASGTSEQTKAVVDGGAIPAFIS
LLASPHAHISEQAVWALGNIAGDGSAFRDLVIKHGAIDPLLALLAVPDLS
TLACGYLRNLTWTLSNLCRNKNPAPPLDAVEQILPTLVRLLHHNDPEVLA
DSCWAISYLTDGPNERIEMVVKKGVVPQLVKLLGATELPIVTPALRAIGN
IVTGTDEQTQKVIDAGALAVFPSLLTNPKTNIQKEATWTMSNITAGRQDQ
IQQVVNHGLVPFLVGVLSKADFKTQKEAAWAITNYTSGGTVEQIVYLVHC
GIIEPLMNLLSAKDTKIIQVILDAISNIFQAAEKLGETEKLSIMIEECGG
LDKIEALQRHENESVYKASLNLIEKYFSV

Ligand information

>5b56 Chain C (length=12) Species: 401671 (HIV-1 M:B_89.6) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

QQRRTRNGASKS

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5b56 Molecular Mechanism of HIV-1 Vpr for Binding to Importin-alpha
Resolution	2.3 Å
Binding residue (original residue number in PDB)	R315 N319 V321 T322 G323 T328 E354 W357 N361 A364 G365 E396 W399 N403 S406 G407
Binding residue (residue number reindexed from 1)	R246 N250 V252 T253 G254 T259 E285 W288 N292 A295 G296 E327 W330 N334 S337 G338

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0061608	nuclear import signal receptor activity

	Biological Process
GO:0006606	protein import into nucleus

	Cellular Component
GO:0005737	cytoplasm

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Cellular Component

External links

PDB	RCSB:5b56, PDBe:5b56, PDBj:5b56
PDBsum	5b56
PubMed	27181198
UniProt	P52293\|IMA1_MOUSE Importin subunit alpha-1 (Gene Name=Kpna2)

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