Structure of PDB 5b4w Chain A Binding Site BS01

Receptor Information

>5b4w Chain A (length=434) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

TAFTPNGTYLQHLARDPTSGTLYLGATNFLFQLSPGLQLEATVSTGPVLD
SRDCLPPVMPDECPQAQPTNNPNQLLLVSPGALVVCGSVHQGVCEQRRLG
QLEQLLLRPERPGDTQYVAANDPAVSTVGLVAQGLAGEPLLFVGRGYTSI
PPITTRALWPPDPQAAFSYEETAKLAVGRLSEYSHHFVSAFARGASAYFL
FLRRDLQAQSRAFRAYVSRVCLRDQHYYSYVELPLACEGGRYGLIQAAAV
ATSREVAHGEVLFAAFSSAGASALCAFPLDEVDRLANRTRDACYTREGRA
EDGTEVAYIEYDVNSDCAQLPVDTLDAYPCGSDHTPSPMASRVPLEATPI
LEWPGIQLTAVAVTMEDGHTIAFLGDSQGQLHRVYLGPGSDGHPYSTQSI
QQGSAVSRDLTFDGTFEHLYVMTQSTLLKVPVAS

Ligand information

>5b4w Chain G (length=16) Species: 32644 (unidentified) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

WRPRVARWTGQIIYCS

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5b4w Allosteric Inhibition of a Semaphorin 4D Receptor Plexin B1 by a High-Affinity Macrocyclic Peptide
Resolution	2.6 Å
Binding residue (original residue number in PDB)	F294 P325 T395 P396 I397 E399 D414 G415 H416 T417 L433 G434 S437
Binding residue (residue number reindexed from 1)	F263 P278 T348 P349 I350 E352 D367 G368 H369 T370 L386 G387 S390

Enzymatic activity

Enzyme Commision number

Gene Ontology

	Molecular Function
GO:0017154	semaphorin receptor activity

	Biological Process
GO:0071526	semaphorin-plexin signaling pathway

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Molecular Function

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Biological Process

External links

PDB	RCSB:5b4w, PDBe:5b4w, PDBj:5b4w
PDBsum	5b4w
PubMed	27984026
UniProt	O43157\|PLXB1_HUMAN Plexin-B1 (Gene Name=PLXNB1)

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