Structure of PDB 5b16 Chain A Binding Site BS01

Receptor Information
>5b16 Chain A (length=722) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VWIRCTHSENYYSSDPMDQVGDSTVVGTSRLRDLYDKFEEELGSRQEKAA
AAAAAAAAAAAAAALWYNDPGQMNDGPLCKCSAKARRTGIRHSIYPGEEA
IKPCRPMTNNAGRLFHYRITVSPPTNFLTDRPTVIEYDDHEYIFEGFSMF
AHAPLTNIPLCKVIRFNIDYTIHFIEEMMPENFCVKGLELFSLFLFRDIL
ELYDWNLKGPCCPRFHFMPRFVRFLPDGGKEVLSMHQILLYLLRCSKAAA
AAAAAAAAAAAAAAAATGIRSDVCQHAMMLPVLTHHIRYHQCLMHLDKLI
GYTFQDRCLLQLAMTHPSHHLNFGMNPDHARNSLSNCGIRQPKYGDTPSR
INHNERLEFLGDAVVEFLTSVHLYYLFPSLEEGGLATYRTAIVQNQHLAM
LAKKLELDRFMLYAHGPDLCRESDLRHAMANCFQALIGAVYLEGSLEEAK
QLFGRLLFNDPDLREVWLNYPLHPLQLQEPNTDRQLIETSPVLQKLTEFE
EAIGVIFTHVRLLARAFTLRTVGFNHLTLGHNQRMEFLGDSIMQLVATEY
LFIHFPDHHEGHLTLLRSSLVNNRTQAKVAEELGMQEYAITNDKTKRPVA
LRTKTLADLLQSFIAALYIDKDLEYVHTFMNVCFFPRLKEFILNQDWNDP
KSQLQQCCLTLRTEGKEPDIPLYKTLQTVGPSHARTYTVAVYFKGERIGC
GKGPSIQQAEMGAAMDALEKYN
Ligand information
>5b16 Chain B (length=25) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
MANLHILSKLQEEMKRLAEEREETR
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5b16 Structure of Human DROSHA
Resolution3.2 Å
Binding residue
(original residue number in PDB)		L987 F988 T998 Y999 A1002 I1003 Q1005 F1069 E1076 V1077 W1078
Binding residue
(residue number reindexed from 1)		L376 F377 T387 Y388 A391 I392 Q394 F458 E465 V466 W467
Enzymatic activity
Enzyme Commision number 3.1.26.3: ribonuclease III.
Gene Ontology
Molecular Function
GO:0003723 RNA binding
GO:0004525 ribonuclease III activity
Biological Process
GO:0006364 rRNA processing
GO:0006396 RNA processing
GO:0031054 pre-miRNA processing

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5b16, PDBe:5b16, PDBj:5b16
PDBsum5b16
PubMed26748718
UniProtQ9NRR4|RNC_HUMAN Ribonuclease 3 (Gene Name=DROSHA)

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