Structure of PDB 5azt Chain A Binding Site BS01

Receptor Information
>5azt Chain A (length=261) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KSLAKRIYEAYLKNFNMNKVKARVILSNNPPFVIHDMETLCMAEKTLVAK
LVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVT
LLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEP
KFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHV
LRLHLQSNHPDDIFLLPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALH
PLLQEIYRDMY
Ligand information
Receptor-Ligand Complex Structure
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PDB5azt 17-OxoDHA Is a PPAR alpha/gamma Dual Covalent Modifier and Agonist
Resolution3.45 Å
Binding residue
(original residue number in PDB)		K292 L302 V306 K310 L459 E462
Binding residue
(residue number reindexed from 1)		K85 L95 V99 K103 L252 E255
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0004879 nuclear receptor activity
Biological Process
GO:0006355 regulation of DNA-templated transcription
Cellular Component
GO:0005634 nucleus

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5azt, PDBe:5azt, PDBj:5azt
PDBsum5azt
PubMed27337155
UniProtQ07869|PPARA_HUMAN Peroxisome proliferator-activated receptor alpha (Gene Name=PPARA)

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