Structure of PDB 5ark Chain A Binding Site BS01

Receptor Information
>5ark Chain A (length=119) Species: 9823 (Sus scrofa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QDRMYQRFLRQHVDPDATGGNDAYCNLMMQRRKMTSHYCKRFNTFIHEDI
WNIRSICSTSNIQCKNGQMNCHEGVVKVTDCRETGSSRAPNCRYRAMAST
RRVVIACEGNPEVPVHFDK
Ligand information
Ligand IDUMP
InChIInChI=1S/C9H13N2O8P/c12-5-3-8(11-2-1-7(13)10-9(11)14)19-6(5)4-18-20(15,16)17/h1-2,5-6,8,12H,3-4H2,(H,10,13,14)(H2,15,16,17)/t5-,6+,8+/m0/s1
InChIKeyJSRLJPSBLDHEIO-SHYZEUOFSA-N
SMILES
SoftwareSMILES
ACDLabs 12.01O=P(O)(O)OCC2OC(N1C(=O)NC(=O)C=C1)CC2O
CACTVS 3.370O[CH]1C[CH](O[CH]1CO[P](O)(O)=O)N2C=CC(=O)NC2=O
OpenEye OEToolkits 1.7.6C1[C@@H]([C@H](O[C@H]1N2C=CC(=O)NC2=O)COP(=O)(O)O)O
CACTVS 3.370O[C@H]1C[C@@H](O[C@@H]1CO[P](O)(O)=O)N2C=CC(=O)NC2=O
OpenEye OEToolkits 1.7.6C1C(C(OC1N2C=CC(=O)NC2=O)COP(=O)(O)O)O
FormulaC9 H13 N2 O8 P
Name2'-DEOXYURIDINE 5'-MONOPHOSPHATE;
DUMP
ChEMBLCHEMBL211312
DrugBankDB03800
ZINCZINC000004228260
PDB chain5ark Chain A Residue 1120 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5ark Structural Basis of Substrate Specificity in Porcine Rnase 4.
Resolution2.28 Å
Binding residue
(original residue number in PDB)		R7 H12 K40 F42 T44 H116 F117 K119
Binding residue
(residue number reindexed from 1)		R7 H12 K40 F42 T44 H116 F117 K119
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) H12 K40 H116 F117 D118
Catalytic site (residue number reindexed from 1) H12 K40 H116 F117 D118
Enzyme Commision number 3.1.27.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding

View graph for
Molecular Function
External links
PDB RCSB:5ark, PDBe:5ark, PDBj:5ark
PDBsum5ark
PubMed26748441
UniProtP15468|RNAS4_PIG Ribonuclease 4 (Gene Name=RNASE4)

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