Structure of PDB 5aox Chain A Binding Site BS01

Receptor Information

>5aox Chain A (length=76) Species: 9606 (Homo sapiens)

PQYQTWEEFSRAAEKLYLADPMKARVVLKYRHSDGNLCVKVTDDLVSLVY
KTDQAQDVKKIEKFHSQLMRLMVAKE

Ligand information

>5aox Chain C (length=87)

ggccgggcgcgguggcucacgccuguaaucccagcacuuugggaggccga
ggcgggaggaucgcgaacacgcgagaccccgucucua

<<<<<<<<<.<<..((>>.>>>>>....<<<<.)).....>>>>>>>><<
<<<<<<.<..<<<<<....>>>>>..>>>>>>>>>..

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5aox Retrotransposition and Crystal Structure of an Alu Rnp in the Ribosome-Stalling Conformation.
• Resolution: 2.04 Å
• Binding residue (original residue number in PDB): P2 Q3 R26 K30 R32 K41 D45 L46 S48 V50
• Binding residue (residue number reindexed from 1): P1 Q2 R25 K29 R31 K40 D44 L45 S47 V49

Gene Ontology

Molecular Function

• GO:0003723 RNA binding
• GO:0005047 signal recognition particle binding
• GO:0005515 protein binding
• GO:0008312 7S RNA binding

Biological Process

• GO:0006614 SRP-dependent cotranslational protein targeting to membrane
• GO:0045900 negative regulation of translational elongation

Cellular Component

• GO:0005737 cytoplasm
• GO:0005785 signal recognition particle receptor complex
• GO:0005786 signal recognition particle, endoplasmic reticulum targeting
• GO:0005829 cytosol
• GO:0048500 signal recognition particle

External links

• PDB: RCSB:5aox, PDBe:5aox, PDBj:5aox
• PDBsum: 5aox
• PubMed: 26585389
• UniProt: P49458|SRP09_HUMAN Signal recognition particle 9 kDa protein (Gene Name=SRP9)