Structure of PDB 5ak9 Chain A Binding Site BS01

Receptor Information
>5ak9 Chain A (length=183) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ENVSGISAYLLGLIIGDGGLYKLKYKGNRSEYRVVITAKSENLIKQHIAP
LMQFLIDELNVKSKIQIVKGDTRYELRVSSKKLYYYFANMLERIRLFNMR
EQIAFIKGLYVAEGDMTLKRLRIWNKNKALLEIVSRWLNNLGVRNTIHLD
DHRHGVYVLNISLRDRIKFVHTILSSHLNPLPP
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5ak9 Engineering a Nickase on the Homing Endonuclease I-Dmoi Scaffold.
Resolution2.601 Å
Binding residue
(original residue number in PDB)		D21 T41 A42 K43 T76 R124 T150 H152 D154 H156 R157 N164 S166 L167
Binding residue
(residue number reindexed from 1)		D17 T37 A38 K39 T72 R120 T146 H148 D150 H152 R153 N160 S162 L163
Binding affinityPDBbind-CN: Kd=0.3nM
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0004519 endonuclease activity
Biological Process
GO:0006314 intron homing
GO:0016539 intein-mediated protein splicing

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5ak9, PDBe:5ak9, PDBj:5ak9
PDBsum5ak9
PubMed26045557
UniProtP21505|DMO1_DESMO Homing endonuclease I-DmoI

[Back to BioLiP]