Structure of PDB 5ah4 Chain A Binding Site BS01

Receptor Information
>5ah4 Chain A (length=380) Species: 1772 (Mycolicibacterium smegmatis) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TDLKFRVVREDFADAVAWVARSLPTRVLAGVLLTGTDEGLTISGFDYEVS
AEVKVSAEIASAGSVLVSGRLLSDITKALPAKPVEVSVEGTRVSLTCGSA
RFSLPTLAVEDYPALPALPEETGVIASDLFAEAIGQVAVAAGRDDTLPML
TGIRVEISGESVVLAATDRFRLAVRELTWVTTAGDVEAAVLVPAKTLAEA
AKAGNQVHLALGSGASVGKDGLLGIRSEGKRSTTRLLDAEFPKFRQLLPA
EHTAVATIGVAELTEAIKRVALVADRGAQIRMEFSDDTLKLSAGADDVGR
AEEDLPVDFAGEPLTIAFNPTYLTDGLGSLHSERVTFGFTTPSRPAVLRP
AGEDDGAGGSGPFPAAKTDYVYLLMPVRLP
Ligand information
Receptor-Ligand Complex Structure
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PDB5ah4 Antibiotics. Targeting Dnan for Tuberculosis Therapy Using Novel Griselimycins.
Resolution2.313 Å
Binding residue
(original residue number in PDB)		R181 F182 R183 E255 L262 P360 M391 V393
Binding residue
(residue number reindexed from 1)		R169 F170 R171 E240 L247 P345 M375 V377
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003887 DNA-directed DNA polymerase activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006260 DNA replication
GO:0006271 DNA strand elongation involved in DNA replication
GO:0046677 response to antibiotic
GO:0071897 DNA biosynthetic process
Cellular Component
GO:0005737 cytoplasm
GO:0009360 DNA polymerase III complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5ah4, PDBe:5ah4, PDBj:5ah4
PDBsum5ah4
PubMed26045430
UniProtA0QND6|DPO3B_MYCS2 Beta sliding clamp (Gene Name=dnaN)

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