Structure of PDB 5a68 Chain A Binding Site BS01

Receptor Information

>5a68 Chain A (length=203) Species: 3702 (Arabidopsis thaliana)

GAMEVEVKLRLLTAAAHLRLTTLLTPYHLKTLHQRNTFFDTPKNDLSLRR
AVLRLRFLQNAPSPPRCIVSLKAKPTLANGISRVEEDEEEIEYWIGKECV
ESPAKLSDIGSRVLKRVKEEYGFNDFLGFVCLGGFENVRNVYEWRGVKLE
VDETKYDFGNCYEIECETEEPERVKTMIEEFLTEEKIEFSNSDMTKFAVF
RSG

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 5a68 Chain A Residue 500

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5a68 Structural Determinants for Substrate Binding and Catalysis in Triphosphate Tunnel Metalloenzymes.
• Resolution: 1.67 Å
• Binding residue (original residue number in PDB): E2 E4 E171
• Binding residue (residue number reindexed from 1): E4 E6 E167
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 3.6.1.-
  3.6.1.25: triphosphatase.

Gene Ontology

Molecular Function

• GO:0005524 ATP binding
• GO:0016462 pyrophosphatase activity
• GO:0016787 hydrolase activity
• GO:0016887 ATP hydrolysis activity
• GO:0050355 inorganic triphosphate phosphatase activity

Biological Process

• GO:0048364 root development

Cellular Component

• GO:0005634 nucleus
• GO:0005680 anaphase-promoting complex
• GO:0005737 cytoplasm

External links

• PDB: RCSB:5a68, PDBe:5a68, PDBj:5a68
• PDBsum: 5a68
• PubMed: 26221030
• UniProt: Q9SIY3|TTM3_ARATH Triphosphate tunnel metalloenzyme 3 (Gene Name=TTM3)