Structure of PDB 4zyo Chain A Binding Site BS01

Receptor Information
>4zyo Chain A (length=298) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
DIYDPTYADAAGPSPKVEYVWRNIILMSLLHLGALYGITLIPTCKFYTWL
WGVFYYFVSALGITAGAHRLWSHRSYKARLPLRLFLIIANTMAFQNDVYE
WARDHRAHHKFSETHADPHNSRRGFFFSHVGWLLVRKHPAVKEKGSTLDL
SDLEAEKLVMFQRRYYKPGLLMMCFILPTLVPWYFWGETFQNSVFVATFL
RYAVVLNATWLVNSAAHLFGYRPYDKNISPRENILVSLGAVGEGFHNYHH
SFPYDYSASEYRWHINFTTFFIDCMAALGLAYDRKKVSKAAILARIKR
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4zyo Chain A Residue 401 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4zyo Crystal structure of human stearoyl-coenzyme A desaturase in complex with substrate.
Resolution3.25 Å
Binding residue
(original residue number in PDB)		H120 H125 H157 H161 H301
Binding residue
(residue number reindexed from 1)		H68 H73 H105 H109 H249
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.19.1: stearoyl-CoA 9-desaturase.
Gene Ontology
Molecular Function
GO:0016717 oxidoreductase activity, acting on paired donors, with oxidation of a pair of donors resulting in the reduction of molecular oxygen to two molecules of water

View graph for
Molecular Function
External links
PDB RCSB:4zyo, PDBe:4zyo, PDBj:4zyo
PDBsum4zyo
PubMed26098317
UniProtO00767|SCD_HUMAN Stearoyl-CoA desaturase (Gene Name=SCD)

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