Structure of PDB 4zw9 Chain A Binding Site BS01

Receptor Information
>4zw9 Chain A (length=470) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MGTQKVTPALIFAITVATIGSFQFGYNTGVINAPEKIIKEFITKTLTDKG
NAPPSEVLLTSLWSLSVAIFSVGGMIGSFSVGLFVNRFGRRNSMLIVNLL
AVTGGCFMGLCKVAKSVEMLILGRLVIGLFCGLCTGFVPMYIGEISPTAL
RGAFGTLNQLGIVVGILVAQIFGLEFILGSEELWPLLLGFTILPAILQSA
ALPFCPESPRFLLINRKEEENAKQILQRLWGTQDVSQDIQEMKDESARMS
QEKQVTVLELFRVSSYRQPIIISIVLQLSQQLSGINAVFYYSTGIFKDAG
VQEPIYATIGAGVVNTIFTVVSLFLVERAGRRTLHMIGLGGMAFCSTLMT
VSLLLKDNYNGMSFVCIGAILVFVAFFEIGPGPIPWFIVAELFSQGPRPA
AMAVAGCSNWTSNFLVGLLFPSAAHYLGAYVFIIFTGFLITFLAFTFFKV
PETRGRTFEDITRAFEGQAH
Ligand information
Ligand IDGLC
InChIInChI=1S/C6H12O6/c7-1-2-3(8)4(9)5(10)6(11)12-2/h2-11H,1H2/t2-,3-,4+,5-,6+/m1/s1
InChIKeyWQZGKKKJIJFFOK-DVKNGEFBSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C1C(C(C(C(O1)O)O)O)O)O
OpenEye OEToolkits 1.5.0C([C@@H]1[C@H]([C@@H]([C@H]([C@H](O1)O)O)O)O)O
CACTVS 3.341OC[CH]1O[CH](O)[CH](O)[CH](O)[CH]1O
CACTVS 3.341OC[C@H]1O[C@H](O)[C@H](O)[C@@H](O)[C@@H]1O
ACDLabs 10.04OC1C(O)C(OC(O)C1O)CO
FormulaC6 H12 O6
Namealpha-D-glucopyranose;
alpha-D-glucose;
D-glucose;
glucose
ChEMBLCHEMBL423707
DrugBank
ZINCZINC000003861213
PDB chain4zw9 Chain A Residue 504 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4zw9 Molecular basis of ligand recognition and transport by glucose transporters
Resolution1.502 Å
Binding residue
(original residue number in PDB)		Q159 I162 I166 Q280 Q281 N286 W386
Binding residue
(residue number reindexed from 1)		Q159 I162 I166 Q280 Q281 N286 W386
Annotation score5
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005353 fructose transmembrane transporter activity
GO:0005354 galactose transmembrane transporter activity
GO:0005515 protein binding
GO:0005536 D-glucose binding
GO:0022857 transmembrane transporter activity
GO:0033300 dehydroascorbic acid transmembrane transporter activity
GO:0055056 D-glucose transmembrane transporter activity
Biological Process
GO:0005975 carbohydrate metabolic process
GO:0015755 fructose transmembrane transport
GO:0015757 galactose transmembrane transport
GO:0019852 L-ascorbic acid metabolic process
GO:0046323 D-glucose import
GO:0055085 transmembrane transport
GO:0070837 dehydroascorbic acid transport
GO:0098708 D-glucose import across plasma membrane
GO:0150104 transport across blood-brain barrier
GO:1904659 D-glucose transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0016235 aggresome
GO:0030667 secretory granule membrane
GO:0035579 specific granule membrane
GO:0042995 cell projection
GO:0043204 perikaryon
GO:0070062 extracellular exosome
GO:0070821 tertiary granule membrane
GO:0101003 ficolin-1-rich granule membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4zw9, PDBe:4zw9, PDBj:4zw9
PDBsum4zw9
PubMed26176916
UniProtP11169|GTR3_HUMAN Solute carrier family 2, facilitated glucose transporter member 3 (Gene Name=SLC2A3)

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