Structure of PDB 4zuh Chain A Binding Site BS01

Receptor Information
>4zuh Chain A (length=298) Species: 28295 (Porcine epidemic diarrhea virus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AGLRKMAQPSGVVEKCIVRVCYGNMALNGLWLGDTVMCPRHVIASSTTST
IDYDYALSVLRLHNFSISSGNVFLGVVGVTMRGALLQIKVNQNNVHTPKY
TYRTVRPGESFNILACYDGAAAGVYGVNMRSNYTIRGSFINGAAGSPGYN
INNGTVEFCYLHQLELGSGCHVGSDLDGVMYGGYEDQPTLQVEGASSLFT
ENVLAFLYAALINGSTWWLSSSRIAVDRFNEWAVHNGMTTVVNTDCFSIL
AAKTGVDVQRLLASIQSLHKNFGGKQILGYTSLTDEFTTGEVIRQMYG
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4zuh Structural basis for the dimerization and substrate recognition specificity of porcine epidemic diarrhea virus 3C-like protease.
Resolution2.394 Å
Binding residue
(original residue number in PDB)		N24 M25 A26 H41 F139 G142 A144 H162 L164 E165 D186 P188 T189
Binding residue
(residue number reindexed from 1)		N24 M25 A26 H41 F139 G142 A144 H162 L164 E165 D186 P188 T189
Enzymatic activity
Catalytic site (original residue number in PDB) H41 G142 A144
Catalytic site (residue number reindexed from 1) H41 G142 A144
Enzyme Commision number 2.1.1.57: methyltransferase cap1.
3.4.19.12: ubiquitinyl hydrolase 1.
3.6.4.12: DNA helicase.
3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0008233 peptidase activity
Biological Process
GO:0019082 viral protein processing

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Molecular Function
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Biological Process
External links
PDB RCSB:4zuh, PDBe:4zuh, PDBj:4zuh
PDBsum4zuh
PubMed27128350
UniProtR4JK63

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