Structure of PDB 4ztx Chain A Binding Site BS01

Receptor Information
>4ztx Chain A (length=768) Species: 5141 (Neurospora crassa) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
VQSSVLGFPRMGVLRDLKKANEAYWADKISQEALLAEGKRLRLAHWKIQK
DAGVDIIPSNDFAHYDHVLDHIQLFNAVPERYTSQKLSPLDEYFAMGRGH
QKGGVDVPALEMVKWFDSNYHYVKPTLQDNQTFSLAKDPKPVREFLEAKE
AGFQTRPVLVGPVSFLALGKADRGSSVDPITLLDKLVPVYVELLKQLKAA
GAESVQIDEPVLVFDLRPEVKAAFKPAYEAIAAAGDAVPKVVVATYFGDI
VHNFDVLPAFSGAAGLHVDLVRNPEQLEPVLKQLGPNQILSAGVVDGRNI
WKNDFAKSLEILQTAVKALGSERVIVATSSSLIHTPHTLASEKKLPSDVY
EWFSFAVEKVKEVATLAKAVTEPEAVKAELEANAAAIKARTDSKRTNDPA
VKERQAQVTPEQHNRKAPFNTRYAEQKKHLSLPLFPTTTIGSFPQTSEIR
VQRNKFTKGEISAEEYERFIEKEIELAVKIQDELDLDVYVHGEPERNDMV
QYFGERLNGYVFTTHAWVQSYGSRCVRPPIIVGDISRPAPMTVKESKYAA
SISKKPMKGMLTGPVTCLRWSFPRVDVHQSVQCQQLALALRDEVVDLEKN
GIYVIQVDEPALREGLPLRKGQEREAYLKWAVDSFKLATAGVENSTQIHS
HFCYSEFQDFFHAIAALDADVLSIENSKSDAKLLKVFIDEEYPRHIGPGV
YDIHSPRVPTLEEFKQRIEEMLAYLKPEQLWINPDCGLKTRKWDEVKGAL
SHMVEAAKYFREKYANKA
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4ztx Chain A Residue 1000 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4ztx Fungal cobalamin-independent methionine synthase: Insights from the model organism, Neurospora crassa.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		H652 C654 E676 C737
Binding residue
(residue number reindexed from 1)		H651 C653 E675 C736
Annotation score1
Enzymatic activity
Enzyme Commision number 2.1.1.14: 5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase.
Gene Ontology
Molecular Function
GO:0003871 5-methyltetrahydropteroyltriglutamate-homocysteine S-methyltransferase activity
GO:0008168 methyltransferase activity
GO:0008172 S-methyltransferase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0008652 amino acid biosynthetic process
GO:0009086 methionine biosynthetic process
GO:0032259 methylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:4ztx, PDBe:4ztx, PDBj:4ztx
PDBsum4ztx
PubMed26657067
UniProtQ8X1E4

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