Structure of PDB 4zrk Chain A Binding Site BS01

Receptor Information
>4zrk Chain A (length=292) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIK
DTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFF
LQVKKQILDEKVYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELL
PKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGV
NYFTIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDK
EFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRR
Ligand information
>4zrk Chain E (length=21) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
PKFGTHHKALQEIRNSLLPFA
Receptor-Ligand Complex Structure
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PDB4zrk Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway
Resolution2.316 Å
Binding residue
(original residue number in PDB)		E136 L140 Y144 L176 Y177 Q178 M179 W191 E194
Binding residue
(residue number reindexed from 1)		E117 L121 Y125 L157 Y158 Q159 M160 W172 E175
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0008092 cytoskeletal protein binding
Cellular Component
GO:0005856 cytoskeleton

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Molecular Function
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Cellular Component
External links
PDB RCSB:4zrk, PDBe:4zrk, PDBj:4zrk
PDBsum4zrk
PubMed26045165
UniProtP46662|MERL_MOUSE Merlin (Gene Name=Nf2)

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