Structure of PDB 4zri Chain A Binding Site BS01

Receptor Information
>4zri Chain A (length=293) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KTFTVRIVTMDAEMEFNCEMKWKGKDLFDLVCRTLGLRETWFFGLQYTIK
DTVAWLKMDKKVLDHDVSKEEPVTFHFLAKFYPENAEEELVQEITQHLFF
LQVKKQILDEKIYCPPEASVLLASYAVQAKYGDYDPSVHKRGFLAQEELL
PKRVINLYQMTPEMWEERITAWYAEHRGRARDEAEMEYLKIAQDLEMYGV
NYFAIRNKKGTELLLGVDALGLHIYDPENRLTPKISFPWNEIRNISYSDK
EFTIKPLDKKIDVFKFNSSKLRVNKLILQLCIGNHDLFMRRRK
Ligand information
>4zri Chain C (length=20) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
GPYQKALREIRYSLLPFANE
Receptor-Ligand Complex Structure
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PDB4zri Angiomotin binding-induced activation of Merlin/NF2 in the Hippo pathway
Resolution2.7 Å
Binding residue
(original residue number in PDB)		E136 N175 L176 Y177 Q178 W184 R187 W191 E206 I210
Binding residue
(residue number reindexed from 1)		E117 N156 L157 Y158 Q159 W165 R168 W172 E187 I191
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0008092 cytoskeletal protein binding
Cellular Component
GO:0005856 cytoskeleton

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Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:4zri, PDBe:4zri, PDBj:4zri
PDBsum4zri
PubMed26045165
UniProtP35240|MERL_HUMAN Merlin (Gene Name=NF2)

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