Structure of PDB 4zr1 Chain A Binding Site BS01

Receptor Information

>4zr1 Chain A (length=274) Species: 559292 (Saccharomyces cerevisiae S288C)

FDSTTFVKELPAEEKLSIATDYSNDYKKHKFLDLNRPLLMQILRSDFKKD
FYVDQIHRPRHYGKGSAPLFGNFLEPLTKTAWWVVPVAWLPVVVYHMGVA
LKNMNQLFACFLFCVGVFVWTLIEYGLHRFLFHFDDWLPESNIAFATHFL
LHGCHHYLPMDKYRLVMPPTLFVILCAPFYKLVFALLPLYWAYAGFAGGL
FGYVCYDECHFFLHHSKLPPFMRKLKKYHLEHHYKNYQLGFGVTSWFWDE
VFGTYLGPDAPLSKMKYESGLEVL

Ligand information

• Ligand ID: ZN
• InChI: InChI=1S/Zn/q+2
• InChIKey: PTFCDOFLOPIGGS-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Zn++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Zn+2]
• Formula: Zn
• Name: ZINC ION
• ChEMBL: CHEMBL1236970
• DrugBank: DB14532
• PDB chain: 4zr1 Chain A Residue 401

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4zr1 The Crystal Structure of an Integral Membrane Fatty Acid alpha-Hydroxylase.
• Resolution: 2.6008 Å
• Binding residue (original residue number in PDB): H271 H326 H330 H345 H349
• Binding residue (residue number reindexed from 1): H155 H210 H214 H229 H233
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 1.14.18.6: 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase.
  1.14.18.7: dihydroceramide fatty acyl 2-hydroxylase.

Gene Ontology

Molecular Function

• GO:0005506 iron ion binding
• GO:0016491 oxidoreductase activity
• GO:0080132 fatty acid 2-hydroxylase activity

Biological Process

• GO:0006629 lipid metabolic process
• GO:0008610 lipid biosynthetic process

Cellular Component

• GO:0016020 membrane

External links

• PDB: RCSB:4zr1, PDBe:4zr1, PDBj:4zr1
• PDBsum: 4zr1
• PubMed: 26515067
• UniProt: Q03529|SCS7_YEAST Ceramide very long chain fatty acid hydroxylase SCS7 (Gene Name=SCS7)