Structure of PDB 4znx Chain A Binding Site BS01

Receptor Information

>4znx Chain A (length=58) Species: 9606 (Homo sapiens)

VTLFVALYDYEARTEDDLSFHKGEKFQILNSSEGDWWEARSLTTGETGYI
PSNYVAPV

Ligand information

>4znx Chain E (length=10) Species: 32630 (synthetic construct)

APPLPPRNRP

Receptor-Ligand Complex Structure

Structure summary

• PDB: 4znx The role of water molecules in the binding of class I and II peptides to the SH3 domain of the Fyn tyrosine kinase.
• Resolution: 2.1 Å
• Binding residue (original residue number in PDB): Y91 Y93 D100 E116 G117 D118 W119 P134 N136 Y137
• Binding residue (residue number reindexed from 1): Y8 Y10 D17 E33 G34 D35 W36 P51 N53 Y54

Enzymatic activity

• Enzyme Commision number: 2.7.10.2: non-specific protein-tyrosine kinase.

External links

• PDB: RCSB:4znx, PDBe:4znx, PDBj:4znx
• PDBsum: 4znx
• PubMed: 27599862
• UniProt: P06241|FYN_HUMAN Tyrosine-protein kinase Fyn (Gene Name=FYN)