Structure of PDB 4zm9 Chain A Binding Site BS01

Receptor Information
>4zm9 Chain A (length=296) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GNPIVVVHGGGAGPISKDRKERVHQGMVRAATVGYGILREGGSAVDAVEG
AVVALEDDPEFNAGCGSVLNTNGEVEMDASIMDGKDLSAGAVSAVQCIAN
PIKLARLVMEKTPHCFLTDQGAAQFAAAMGVPEIPGEKLVTERNKKRLEK
EKHETVGAVALDCKGNVAYATSTGGIVNKMVGRVGDSPCLGAGGYADNDI
GAVSTTGHGESILKVNLARLTLFHIEQGKTVEEAADLSLGYMKSRVKGLG
GLIVVSKTGDWVAKWTSTSMPWAAAKDGKLHFGIDPDDTTITDLPG
Ligand information
Ligand IDGLY
InChIInChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChIKeyDHMQDGOQFOQNFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C(=O)O)N
CACTVS 3.341NCC(O)=O
ACDLabs 10.04O=C(O)CN
FormulaC2 H5 N O2
NameGLYCINE
ChEMBLCHEMBL773
DrugBankDB00145
ZINCZINC000004658552
PDB chain4zm9 Chain A Residue 402 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4zm9 Intramolecular Cleavage of the hASRGL1 Homodimer Occurs in Two Stages.
Resolution2.51 Å
Binding residue
(original residue number in PDB)		R196 D199 G220 G222
Binding residue
(residue number reindexed from 1)		R183 D186 G207 G209
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) N62 T168 T186 R196 T219 G220
Catalytic site (residue number reindexed from 1) N62 T155 T173 R183 T206 G207
Enzyme Commision number 3.4.19.5: beta-aspartyl-peptidase.
3.5.1.1: asparaginase.
Gene Ontology
Molecular Function
GO:0004067 asparaginase activity
GO:0016787 hydrolase activity

View graph for
Molecular Function
External links
PDB RCSB:4zm9, PDBe:4zm9, PDBj:4zm9
PDBsum4zm9
PubMed26780688
UniProtQ7L266|ASGL1_HUMAN Isoaspartyl peptidase/L-asparaginase (Gene Name=ASRGL1)

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