Structure of PDB 4zgy Chain A Binding Site BS01

Receptor Information
>4zgy Chain A (length=383) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TAKDILDQKINEKDAFYVADLGDILKKHLRWLKALPRVTPFYAVKCNDSK
AIVKTLAATGTGFDCASKTEIQLVQSLGVPPERIIYANPCKQVSQIKYAA
NNGVQMMTFDSEVELMKVARAHPKAKLVLRIATDDSCRLSVKFGATLRTS
RLLLERAKELNIDVVGVSFHVGSGCTDPETFVQAISDARCVFDMGAEVGF
SMYLLDIGGGFPGSEDVKLKFEEITGVINPALDKYFPSDSGVRIIAEPGR
YYVASAFTLAVNIIAKKIVLKEQTGSSEQTFMYYVNDGVYGSFNCILYDH
AHVKPLLQKRPEKYYSSSIWGPTCDGLDRIVERCDLPEMHVGDWMLFENM
GAYTVASTFNGFQRPTIYYVMSGPAWQLMQQFQ
Ligand information
Ligand IDPLP
InChIInChI=1S/C8H10NO6P/c1-5-8(11)7(3-10)6(2-9-5)4-15-16(12,13)14/h2-3,11H,4H2,1H3,(H2,12,13,14)
InChIKeyNGVDGCNFYWLIFO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341Cc1ncc(CO[P](O)(O)=O)c(C=O)c1O
OpenEye OEToolkits 1.5.0Cc1c(c(c(cn1)COP(=O)(O)O)C=O)O
ACDLabs 10.04O=P(O)(O)OCc1cnc(c(O)c1C=O)C
FormulaC8 H10 N O6 P
NamePYRIDOXAL-5'-PHOSPHATE;
VITAMIN B6 Phosphate
ChEMBLCHEMBL82202
DrugBankDB00114
ZINCZINC000001532514
PDB chain4zgy Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4zgy Structural basis of antizyme-mediated regulation of polyamine homeostasis
Resolution2.63 Å
Binding residue
(original residue number in PDB)		K69 D88 H197 G237 E274 G276 R277 Y389
Binding residue
(residue number reindexed from 1)		K45 D64 H170 G210 E247 G249 R250 Y353
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) K69 H197 E274
Catalytic site (residue number reindexed from 1) K45 H170 E247
Enzyme Commision number 4.1.1.17: ornithine decarboxylase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0004586 ornithine decarboxylase activity
GO:0005515 protein binding
GO:0016831 carboxy-lyase activity
GO:0042803 protein homodimerization activity
Biological Process
GO:0001822 kidney development
GO:0006595 polyamine metabolic process
GO:0006596 polyamine biosynthetic process
GO:0008283 cell population proliferation
GO:0008284 positive regulation of cell population proliferation
GO:0009615 response to virus
GO:0033387 putrescine biosynthetic process from ornithine
GO:0042176 regulation of protein catabolic process
Cellular Component
GO:0005575 cellular_component
GO:0005737 cytoplasm
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4zgy, PDBe:4zgy, PDBj:4zgy
PDBsum4zgy
PubMed26305948
UniProtP11926|DCOR_HUMAN Ornithine decarboxylase (Gene Name=ODC1)

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