Structure of PDB 4z96 Chain A Binding Site BS01

Receptor Information

>4z96 Chain A (length=523) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

GPLGSEAHLYMQVQIVAEDQFCGHQGNDMYDEEKVKYTVFKVLKNSSLAE
FVQSLSQTMGFPQDQIRLWPMQARSNGTKRPAMLDNEADGNKTMIELSDN
ENPWTIFLETVDPELAASGATLPKFDKDHDVMLFLKMYDPKTRSLNYCGH
IYTPISCKIRDLLPVMCDRAGFIQDTSLILYEEVKPNLTERIQDYDVSLD
KALDELMDGDIIVFQKDDPENDNSELPTAKEYFRDLYHRVDVIFCDKTIP
NDPGFVVTLSNRMNYFQVAKTVAQRLNTDPMLLQFFKSQGYRDGPGNPLR
HNYEGTLRDLLQFFKPRQPKKLYYQQLKMKITDFENRRSFKCIWLNSQFR
EEEITLYPDKHGCVRDLLEECKKAVELGEKASGKLRLLEIVSYKIIGVHQ
EDELLECLSPATSRTFRIEEIPLDQVDIDNEMLVTVAHFHKEVFGTFGIP
FLLRIQGEHFREVMKRIQSLLDIQEEFEKFKFAIVMMGRHQYINEDEYEN
LKDFEPQPGMSHPRPWLGLDHFN

Ligand information

>4z96 Chain C (length=8) Species: 9606 (Homo sapiens) [Search peptide sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

NKGKGKGK

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4z96 Crystal structure of DNMT1 in complex with USP7
Resolution	2.85 Å
Binding residue (original residue number in PDB)	Q626 A627 R628 S629 N630 K681 D684 I709 E744 D754 D758 E759 L760 D762 D764
Binding residue (residue number reindexed from 1)	Q72 A73 R74 S75 N76 K127 D130 I155 E190 D200 D204 E205 L206 D208 D210

Enzymatic activity

Enzyme Commision number

3.4.19.12: ubiquitinyl hydrolase 1.

External links

PDB	RCSB:4z96, PDBe:4z96, PDBj:4z96
PDBsum	4z96
PubMed
UniProt	Q93009\|UBP7_HUMAN Ubiquitin carboxyl-terminal hydrolase 7 (Gene Name=USP7)

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