Structure of PDB 4z4q Chain A Binding Site BS01

Receptor Information
>4z4q Chain A (length=690) Species: 170187 (Streptococcus pneumoniae TIGR4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAK
AKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHI
QTLLLTFFYRYMRPLVEAGHVYIALPPLYKAYAWTDGELEELRKLQRYKG
LGEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKW
IEDNVKFTNIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRI
LYSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKN
REILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWN
FDDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMI
DHPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEI
EKLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRD
GLRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVGIVP
ILSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRA
SENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELRE
KIAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLED
Ligand information
Receptor-Ligand Complex Structure
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PDB4z4q Structural studies of the drug-stabilized cleavage complexes of topoisomerase IV and gyrase from Streptococcus pneumoniae
Resolution3.04 Å
Binding residue
(original residue number in PDB)		D510 R1028 K1038 H1074 H1076 S1080 R1087 K1093 T1168 I1170
Binding residue
(residue number reindexed from 1)		D96 R234 K244 H280 H282 S286 R293 K299 T374 I376
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4z4q, PDBe:4z4q, PDBj:4z4q
PDBsum4z4q
PubMed
UniProtP72525|PARC_STRPN DNA topoisomerase 4 subunit A (Gene Name=parC);
Q59961|PARE_STRPN DNA topoisomerase 4 subunit B (Gene Name=parE)

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