Structure of PDB 4z4p Chain A Binding Site BS01

Receptor Information
>4z4p Chain A (length=161) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
TLHSKSSQYRRLRTEWKNNVYLARSRIQGLGLYAAKDLEKHTMVIEYIGT
IIRNEVANRREKIYEEQNRGIYMFRINNEHVIDATLTGGPARYINHSCAP
NCVAEVVTFDKEDKIIIISSRRIPKGEELTYDYQFDFEDDQHEIPCHCGA
WNCRKWMKGHH
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain4z4p Chain A Residue 5601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4z4p Evolving Catalytic Properties of the MLL Family SET Domain.
Resolution2.2 Å
Binding residue
(original residue number in PDB)		C5477 C5525 C5527 C5532
Binding residue
(residue number reindexed from 1)		C98 C146 C148 C153
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) Y5426 I5502
Catalytic site (residue number reindexed from 1) Y47 I123
Enzyme Commision number 2.1.1.364: [histone H3]-lysine(4) N-methyltransferase.
External links
PDB RCSB:4z4p, PDBe:4z4p, PDBj:4z4p
PDBsum4z4p
PubMed26320581
UniProtO14686|KMT2D_HUMAN Histone-lysine N-methyltransferase 2D (Gene Name=KMT2D)

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