Structure of PDB 4z3o Chain A Binding Site BS01

Receptor Information
>4z3o Chain A (length=689) Species: 170187 (Streptococcus pneumoniae TIGR4) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KLTPAQSKNPAKNELYLVEGDSAGGSAKQGRDRKFQAILPLRGKVINTAK
AKMADILKNEEINTMIYTIGAGVGADFSIEDANYDKIIIMTDADTDGAHI
QTLLLTFFYRYMRPLVEAGHVYIALPPLYKYAWTDGELEELRKLQRYKGL
GEMNADQLWETTMNPETRTLIRVTIEDLARAERRVNVLMGDKVEPRRKWI
EDNVKFTNIQNMSLEDIMGERFGRYSKYIIQDRALPDIRDGLKPVQRRIL
YSMNKDSNTFDKSYRKSAKSVGNIMGNFHPHGDSSIYDAMVRMSQNWKNR
EILVEMHGNNGSMDGDPPAAMRYTEARLSEIAGYLLQDIEKKTVPFAWNF
DDTEKEPTVLPAAFPNLLVNGSTGISAGYATDIPPHNLAEVIDAAVYMID
HPTAKIDKLMEFLPGPDFPTGAIIQGRDEIKKAYETGKGRVVVRSKTEIE
KLKGGKEQIVITEIPYEINKANLVKKIDDVRVNNKVAGIAEVRDESDRDG
LRIAIELKKDANTELVLNYLFKYTDLQINYNFNMVAIDNFTPRQVGIVPI
LSSYIAHRREVILARSRFDKEKAEKRLHIVEGLIRVISILDEVIALIRAS
ENKADAKENLKVSYDFTEEQAEAIVTLQLYRLTNTDVVVLQEEEAELREK
IAMLAAIIGDERTMYNLMKKELREVKKKFATPRLSSLED
Ligand information
Receptor-Ligand Complex Structure
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PDB4z3o Structural studies of the drug-stabilized cleavage complexes of topoisomerase IV and gyrase from Streptococcus pneumoniae
Resolution3.44 Å
Binding residue
(original residue number in PDB)		G434 D435 S436
Binding residue
(residue number reindexed from 1)		G20 D21 S22
Enzymatic activity
Enzyme Commision number 5.6.2.2: DNA topoisomerase (ATP-hydrolyzing).
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003918 DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity
GO:0005524 ATP binding
Biological Process
GO:0006259 DNA metabolic process
GO:0006265 DNA topological change
Cellular Component
GO:0005694 chromosome

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:4z3o, PDBe:4z3o, PDBj:4z3o
PDBsum4z3o
PubMed
UniProtP72525|PARC_STRPN DNA topoisomerase 4 subunit A (Gene Name=parC);
Q59961|PARE_STRPN DNA topoisomerase 4 subunit B (Gene Name=parE)

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