Structure of PDB 4z31 Chain A Binding Site BS01
Receptor Information
>4z31 Chain A (length=293) Species:
9606
(Homo sapiens) [
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NKHYEVAKKCVEDLALYLKPALSRPMQRKLVTLVNCQLVEEEGRVRAMRA
ARSLGERTVTELILQHQNPQQLSANLWAAVRARGCQFLGPAMQEEALKLV
LLALEDGSALSRKVLVLFVVQRLEPRFPQASKTSIGHVVQLLYRASCFKV
TKRDEDSSLMQLKEEFRSYEALRREHDAQIVHIAMEAGLRISPEQWSSLL
YGDLAHKSHMQSIIDKLQSPESFAKSVQELTIVLQRTGDPANLNRLRPHL
ELLANIDPNPDAVSPTWEQLENAMVAVKTVVHGLVDFIQNYSR
Ligand information
>4z31 Chain C (length=14) [
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uguucugugaacac
..............
Receptor-Ligand Complex Structure
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PDB
4z31
New Insights into the RNA-Binding and E3 Ubiquitin Ligase Activities of Roquins.
Resolution
2.5 Å
Binding residue
(original residue number in PDB)
S312 Q315 S316 D319
Binding residue
(residue number reindexed from 1)
S208 Q211 S212 D215
Binding affinity
PDBbind-CN
: Kd=356nM
Enzymatic activity
Enzyme Commision number
2.3.2.27
: RING-type E3 ubiquitin transferase.
External links
PDB
RCSB:4z31
,
PDBe:4z31
,
PDBj:4z31
PDBsum
4z31
PubMed
26489670
UniProt
Q9HBD1
|RC3H2_HUMAN Roquin-2 (Gene Name=RC3H2)
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