Structure of PDB 4z0c Chain A Binding Site BS01

Receptor Information

>4z0c Chain A (length=709) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

YGFNKCTQYEFDIHHVLCIRKKITNLTEAISDIPRYTTHLNLTHNEIQVL
PPWSFTNLSALVDLRLEWNSIWKIDEGAFRGLENLTLLNLVENKIQSVNN
SFEGLSSLKTLLLSHNQITHIHKDAFTPLIKLKYLSLSRNNISDFSGILE
AVQHLPCLERLDLTNNSIMYLDHSPRSLVSLTHLSFEGNKLRELNFSALS
LPNLTNLSASRNGNKVIQNVYLKTLPQLKSLNLSGTVIKLENLSAKHLQN
LRAMDLSNWELRHGHLDMKTVCHLLGNLPKLETLVFQKNVTNAEGIKQLA
KCTRLLFLDLGQNSDLIYLNDSEFNALPSLQKLNLNKCQLSFINNRTWSS
LQNLTSLDLSHNKFKSFPDFAFSPLKHLEFLSLSRNPITELNNLAFSGLF
ALKELNLAACWIVTIDRYSFTQFPNLEVLDLGDNNIRTLNHGTFRPLKKL
QSLILSHNCLKILEPNSFSGLTNLRSLDLMYNSLSYFHEHLFSGLEKLLI
LKLGFNKITYETTRTLQYPPFIKLKSLKQLNLEGQRHGIQVVPSNFFQGL
GSLQELLLGKNPSVFLDHHQFDPLINLTKLDISGTKDGDRSLYLNASLFQ
NLKRLKILRLENNNLESLVPDMFSSLQSLQVFSLRFNNLKVINQSHLKNL
KSLMFFDVYGNKLQCTCDNLWFKNWSMNTEEVHIPFLRSYPCQQPGSQSL
LIDFDDAMC

Ligand information

>4z0c Chain B (length=13) [Search RNA sequence] [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

acggaaagacccc

.............

Receptor-Ligand Complex Structure

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Structure summary

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PDB	4z0c Structural basis for specific recognition of single-stranded RNA by Toll-like receptor 13
Resolution	2.3 Å
Binding residue (original residue number in PDB)	Y77 E78 L85 R88 W136 E160 R207 S524 H525 D546 M548 Y549 K570 E601 K628 R677 E679 N680 R703 F704
Binding residue (residue number reindexed from 1)	Y9 E10 L17 R20 W68 E92 R139 S456 H457 D478 M480 Y481 K502 E533 K560 R609 E611 N612 R635 F636

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:4z0c, PDBe:4z0c, PDBj:4z0c
PDBsum	4z0c
PubMed	26323037
UniProt	Q6R5N8\|TLR13_MOUSE Toll-like receptor 13 (Gene Name=Tlr13)

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