Structure of PDB 4yzw Chain A Binding Site BS01

Receptor Information
>4yzw Chain A (length=678) Species: 7165 (Anopheles gambiae) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MATLTQKFHGLLQHPLEPLFLPKNDGTLFYDLPERFLTSRYSPIGQNLAN
RFGPNSPATGVPPTVVTIKDLDELPDLTFATWIKRRDSFSLFNPEHRKAA
GKLTKLFLDQPNADRLVDVAAYARDRLNAPLFQYALSVALLHRPDTKSVS
VPSLLHLFPDQFIDPAAQVRMMEEGSIVLDENRMPIPIPMNYTATDAEPE
QRMAFFREDIGVNLHHWHWHLVYPASGPPDVVRKDRRGELFYYMHQQLLA
RYQIDRYAQGLGRIEPLANLREPVREAYYPKLLRTSNNRTFCPRYPGMTI
SDVARSADRLEVRIADIESWLPRVLEAIDAGFAVSDDGVRVPLDETRGID
VLGNILERSAISINRNLYGDVHNMGHVLLAFIHDPRGTYLESSGVMGGVA
TAMRDPIFYRWHKFIDNIFLRNKARLAPYTMAELSNSNVTLEALETQLDR
AGGAVNSFVTFWQRSQVDLRAGIDFSAAGSAFVSFTHLQCAPFVYRLRIN
STARSNRQDTVRIFLLPRQNEQGRPLSFEDRRLLAIELDSFRVNLRPGMN
NIVRQSSNSSVTIPFERTFGNVQSRFCGCGWPAHMLLPKGNANGVEFDLF
AMVSRFEDDNANVNAGCDDSYAFCGLRDRVYPSRRAMGFPFDRRASNGVR
SVADFVAPYKNMRLATVTLRFMNTIIDR
Ligand information
Ligand IDCU
InChIInChI=1S/Cu/q+2
InChIKeyJPVYNHNXODAKFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Cu+2]
CACTVS 3.341[Cu++]
FormulaCu
NameCOPPER (II) ION
ChEMBL
DrugBankDB14552
ZINC
PDB chain4yzw Chain A Residue 801 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB4yzw The structure of a prophenoloxidase (PPO) from Anopheles gambiae provides new insights into the mechanism of PPO activation.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		H223 H227 H252
Binding residue
(residue number reindexed from 1)		H216 H220 H245
Annotation score1
Enzymatic activity
Enzyme Commision number 1.10.3.-
1.14.18.-
Gene Ontology
Molecular Function
GO:0004097 catechol oxidase activity
GO:0004497 monooxygenase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Cellular Component
GO:0005576 extracellular region

View graph for
Molecular Function
View graph for
Cellular Component
External links
PDB RCSB:4yzw, PDBe:4yzw, PDBj:4yzw
PDBsum4yzw
PubMed26732497
UniProtQ8MZM3|PPO8_ANOGA Phenoloxidase 8 (Gene Name=PPO8)

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