Structure of PDB 4yr0 Chain A Binding Site BS01

Receptor Information
>4yr0 Chain A (length=421) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVQYKSWKGGGII
AVSYEARAFGVTMSMWADDAKKLCPDLLLAQVRESRGKANLTKYREASVE
VMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLGQPISADLLPSTYIEG
LPQVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAIERE
TGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRKIRS
LGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRGIEH
DPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTKDRN
DNDRVATQLVVSIRVQGDKRLSSLRRCCALTRYDAHKMSHDAFTVIKNCN
TSEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
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PDB4yr0 Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
Resolution1.78 Å
Binding residue
(original residue number in PDB)		Q38 Y39 W42 W64 K86 R93 R313 P316 K317 T318 G320 S322 K323 N324 P326 R351
Binding residue
(residue number reindexed from 1)		Q40 Y41 W44 W66 K88 R95 R306 P309 K310 T311 G313 S315 K316 N317 P319 R344
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4yr0, PDBe:4yr0, PDBj:4yr0
PDBsum4yr0
PubMed25947374
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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