Structure of PDB 4yp3 Chain A Binding Site BS01

Receptor Information
>4yp3 Chain A (length=424) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GPHMATGQDRVVALVDMDCFFVQVEQRQNPHLRNKPCAVVAYKSWKGGGI
IAVSYEARAFGVTASMWADDAKKLCPDLLLAQVRESRGKANLTKYREASV
EVMEIMSRFAVIERASIDEAYVDLTSAVQERLQKLQGQPISADLLPSTYI
EGLPQTVQKEGMRKQGLFQWLDSLQIDNLTSPDLQLTVGAVIVEEMRAAI
ERETGFQCSAGISHNKVLAKLACGLNKPNRQTLVSHGSVPQLFSQMPIRK
IRSLGGKLGASVIEILGIEYMGELTQFTESQLQSHFGEKNGSWLYAMCRG
IEHDPVKPRQLPKTIGCSKNFPGKTALATREQVQWWLLQLAQELEERLTK
DRNDNDRVATQLVVSIRVQGSSLRRCCALTRYDAHKMSHDAFTVIKNCNT
SGIQTEWSPPLTMLFLCATKFSAS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4yp3 Roles of Residues Arg-61 and Gln-38 of Human DNA Polymerase eta in Bypass of Deoxyguanosine and 7,8-Dihydro-8-oxo-2'-deoxyguanosine.
Resolution1.89 Å
Binding residue
(original residue number in PDB)		Y39 W42 W64 K86 R93 R313 P316 K317 T318 G320 C321 S322 K323 N324 P326 R351
Binding residue
(residue number reindexed from 1)		Y42 W45 W67 K89 R96 R309 P312 K313 T314 G316 C317 S318 K319 N320 P322 R347
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003684 damaged DNA binding
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:4yp3, PDBe:4yp3, PDBj:4yp3
PDBsum4yp3
PubMed25947374
UniProtQ9Y253|POLH_HUMAN DNA polymerase eta (Gene Name=POLH)

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