Structure of PDB 4yk6 Chain A Binding Site BS01

Receptor Information
>4yk6 Chain A (length=339) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HHHMLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAVCV
LMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAG
MALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLS
WRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTEN
KADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDH
RQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMG
AVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYKDAN
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4yk6 Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners
Resolution1.7 Å
Binding residue
(original residue number in PDB)		F458 M503 T506 N507 F510 G511 K516 Q542 R549 N550 W553 R554 S590 W593 N594 A597 H598 N641
Binding residue
(residue number reindexed from 1)		F56 M101 T104 N105 F108 G109 K114 Q140 R147 N148 W151 R152 S188 W191 N192 A195 H196 N239
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008013 beta-catenin binding
Biological Process
GO:0030178 negative regulation of Wnt signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:4yk6, PDBe:4yk6, PDBj:4yk6
PDBsum4yk6
PubMed27462415
UniProtP25054|APC_HUMAN Adenomatous polyposis coli protein (Gene Name=APC)

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