Structure of PDB 4yje Chain A Binding Site BS01

Receptor Information
>4yje Chain A (length=336) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
HHHMLHLLEQIRAYCETCWEWQEAHEPGMDQDKNPMPAPVEHQICPAVCV
LMKLSFDEEHRHAMNELGGLQAIAELLQVDCEMYGLTNDHYSITLRRYAG
MALTNLTFGDVANKATLCSMKGCMRALVAQLKSESEDLQQVIASVLRNLS
WRADVNSKKTLREVGSVKALMECALEVKKESTLKSVLSALWNLSAHCTEN
KADICAVDGALAFLVGTLTYRSQTNTLAIIESGGGILRNVSSLIATNEDH
RQILRENNCLQTLLQHLKSHSLTIVSNACGTLWNLSARNPKDQEALWDMG
AVSMLKNLIHSKHKMIAMGSAAALRNLMANRPAKYK
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB4yje Structures of the APC-ARM domain in complexes with discrete Amer1/WTX fragments reveal that it uses a consensus mode to recognize its binding partners
Resolution1.9 Å
Binding residue
(original residue number in PDB)		F458 M503 T506 N507 F510 G511 K516 R549 N550 W553 S590 W593 N594 A597 N641 N679 M717
Binding residue
(residue number reindexed from 1)		F56 M101 T104 N105 F108 G109 K114 R147 N148 W151 S188 W191 N192 A195 N239 N277 M315
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0008013 beta-catenin binding
Biological Process
GO:0030178 negative regulation of Wnt signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:4yje, PDBe:4yje, PDBj:4yje
PDBsum4yje
PubMed27462415
UniProtP25054|APC_HUMAN Adenomatous polyposis coli protein (Gene Name=APC)

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